{"product_id":"zebrafish-lc3b-antibody-map1lc3b-bha17102302","title":"Zebrafish LC3B Antibody \/ MAP1LC3B","description":"Microtubule-associated proteins 1A\/1B light chain 3B (Map1lc3b) is a highly conserved autophagy-related protein in zebrafish (Danio rerio), serving as a key component of the autophagosome membrane. It is the zebrafish ortholog of mammalian LC3B, which is widely used as a molecular marker for autophagosomes and autophagic activity.\u003cp\u003eZebrafish Map1lc3b is initially synthesized as a cytosolic precursor (LC3-I), which undergoes post-translational cleavage and lipidation to form LC3-II, the autophagosome-associated form. This lipidated form binds to autophagic membranes, making Map1lc3b essential for autophagosome formation, maturation, and cargo recruitment.\u003c\/p\u003e\u003cp\u003eIn zebrafish, map1lc3b is expressed during early embryogenesis and throughout development, with increased expression observed in tissues undergoing high autophagic flux. It has become a widely used marker in transgenic zebrafish lines (e.g., Tg(CMV:map1lc3b-GFP)) for live imaging of autophagy under physiological and stress conditions, including nutrient deprivation, neurodegeneration, and toxin exposure.\u003c\/p\u003e\u003cp\u003eThe conserved role of Map1lc3b in autophagy makes it an important tool for studying cellular homeostasis, developmental processes, and disease models in zebrafish.\n\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53042927436141,"sku":"F53289-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53043009192301,"sku":"F53289-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6a399fe1-aef8-4b5d-b646-4ca90851ddad.jpg?v=1771923997","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-lc3b-antibody-map1lc3b-bha17102302","provider":"BioHippo","version":"1.0","type":"link"}