{"product_id":"zebrafish-lhcgr-antibody-lutropin-choriogonadotropic-hormone-receptor-bha17136382","title":"Zebrafish Lhcgr Antibody \/ Lutropin-choriogonadotropic hormone receptor","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Lhcgr Antibody \/ Lutropin-choriogonadotropic hormone receptor is a anti-Zebrafish Lhcgr Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Zebrafish Lhcgr\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLuteinizing hormone\/choriogonadotropin receptor (Lhcgr) is a G protein-coupled receptor that mediates the actions of luteinizing hormone (LH) and chorionic gonadotropin (CG). In zebrafish (Danio rerio), Lhcgr plays a crucial role in gonadal development and function, including steroidogenesis, oocyte maturation, and ovulation.\u003cp\u003eZebrafish lhcgr is primarily expressed in the gonads, where it facilitates LH signaling necessary for reproductive maturation and fertility. Activation of Lhcgr triggers downstream signaling cascades, including cAMP\/PKA pathways, leading to the production of sex steroids such as estradiol and testosterone. Functional studies in zebrafish have shown that Lhcgr is essential for proper follicular development and ovulation in females, and for Leydig cell function in males.\u003c\/p\u003e\n\u003cp\u003eAs a conserved reproductive hormone receptor, zebrafish Lhcgr is a valuable model for investigating vertebrate reproductive endocrinology, hormone receptor signaling, and the genetic basis of fertility and gonadal disorders.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Zebrafish+Lhcgr - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Zebrafish+Lhcgr - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Zebrafish+Lhcgr - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Zebrafish+Lhcgr - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zebrafish+Lhcgr+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327654253,"sku":"RZ1187","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ee9b4a5f-b468-4f75-bdee-b5f244f44b3a.jpg?v=1772019454","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-lhcgr-antibody-lutropin-choriogonadotropic-hormone-receptor-bha17136382","provider":"BioHippo","version":"1.0","type":"link"}