{"product_id":"zebrafish-lysozyme-antibody-lyz-bha17136431","title":"Zebrafish Lysozyme Antibody \/ Lyz","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Lysozyme Antibody \/ Lyz is a anti-Zebrafish Lysozyme Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Zebrafish Lysozyme\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eLysozyme is an antimicrobial enzyme that plays a key role in the innate immune system by breaking down bacterial cell walls. In zebrafish, lysozyme is expressed in immune cells such as neutrophils and macrophages and contributes to the early defense against bacterial infections.\u003cp\u003eLysozyme functions by cleaving the glycosidic bonds in peptidoglycan, a major structural component of bacterial cell walls, particularly in gram positive bacteria. This activity leads to bacterial lysis and supports the clearance of pathogens from the host. In zebrafish, lysozyme genes are expressed during embryogenesis and are upregulated in response to infection or immune stimulation, making them important markers of immune activation.\u003c\/p\u003e\n\u003cp\u003eZebrafish lysozyme is highly conserved with its mammalian counterparts and is commonly used in research focused on host pathogen interactions, inflammation, and immune system development. It is also a valuable tool for studying the effects of genetic mutations, environmental exposures, or pharmaceuticals on immune responses in vivo.\u003c\/p\u003e\n\u003cp\u003eBecause of the transparency of zebrafish embryos and the availability of immune cell specific transgenic lines, lysozyme expression can be visualized and quantified in real time during infection and inflammation models. This makes zebrafish lysozyme a widely used marker in developmental immunology and disease research.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Zebrafish+Lysozyme - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Zebrafish+Lysozyme - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Zebrafish+Lysozyme - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Zebrafish+Lysozyme - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zebrafish+Lysozyme+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328899437,"sku":"RZ1236","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_60f6e555-6d67-4b35-877a-bec847bae2fc.jpg?v=1772019463","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-lysozyme-antibody-lyz-bha17136431","provider":"BioHippo","version":"1.0","type":"link"}