{"product_id":"zebrafish-mmp9-antibody-matrix-metalloproteinase-9-bha17136434","title":"Zebrafish Mmp9 Antibody \/ Matrix metalloproteinase 9","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Mmp9 Antibody \/ Matrix metalloproteinase 9 is a anti-MMP9 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasmic, nuclear, secreted.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MMP9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMmp9, or matrix metalloproteinase nine, is a zinc dependent endopeptidase that plays a central role in extracellular matrix remodeling during development, inflammation, and tissue repair. In zebrafish, Mmp9 is involved in multiple biological processes including fin regeneration, immune response, and neuronal development.\u003cp\u003eMmp9 functions by degrading components of the extracellular matrix such as collagen and gelatin, allowing for tissue restructuring and cell migration. Its expression is tightly regulated and often induced by injury, infection, or developmental cues. In zebrafish, Mmp9 is notably upregulated in response to fin amputation and participates in the regeneration process by clearing damaged matrix and enabling cell proliferation.\u003c\/p\u003e\n\u003cp\u003eIn the immune system, zebrafish Mmp9 is expressed in neutrophils and macrophages and contributes to leukocyte recruitment and inflammation resolution. It is also involved in remodeling of the brain and other organs during development and in response to environmental stressors.\u003c\/p\u003e\n\u003cp\u003eDue to its conservation across vertebrate species, zebrafish Mmp9 serves as a powerful model for studying matrix dynamics, regenerative biology, and inflammatory diseases. It is commonly used in genetic and chemical screens to explore pathways related to tissue remodeling and immune function.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MMP9 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MMP9 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MMP9 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MMP9 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MMP9+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047329423725,"sku":"RZ1239","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4cff55f0-1066-4a6e-8325-e9135ffa0060.jpg?v=1772019464","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-mmp9-antibody-matrix-metalloproteinase-9-bha17136434","provider":"BioHippo","version":"1.0","type":"link"}