{"product_id":"zebrafish-mpeg1-antibody-mpeg1-1-macrophage-expressed-gene-1-bha17136435","title":"Zebrafish Mpeg1 Antibody \/ Mpeg1.1 \/ Macrophage-expressed gene 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Mpeg1 Antibody \/ Mpeg1.1 \/ Macrophage-expressed gene 1 is a anti-MPEG1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MPEG1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMpeg1.1, or macrophage expressed gene 1.1, is a membrane attack complex and perforin domain containing protein that plays a key role in the innate immune response of zebrafish. It is primarily expressed in macrophages and other phagocytic cells and functions in the recognition and destruction of pathogens.\u003cp\u003eMpeg1.1 is part of a family of pore forming proteins that contribute to host defense by disrupting the membranes of invading microorganisms. In zebrafish, Mpeg1.1 is used as a specific marker for macrophages and is widely expressed in immune tissues during both embryonic development and adulthood. Its expression can be induced by infection, tissue injury, or immune activation.\u003c\/p\u003e\n\u003cp\u003eZebrafish Mpeg1.1 has been extensively used in transgenic reporter lines to study macrophage behavior, immune surveillance, and inflammatory responses in vivo. These models have provided important insights into the dynamics of macrophage recruitment, phagocytosis, and pathogen clearance.\u003c\/p\u003e\n\u003cp\u003eBecause of its evolutionary conservation and strong immune specificity, zebrafish Mpeg1.1 is a valuable tool in immunology, host pathogen interaction studies, and high throughput drug screening aimed at modulating the innate immune system.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MPEG1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MPEG1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MPEG1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MPEG1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MPEG1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047329063277,"sku":"RZ1240","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c7a33b75-b1c6-443a-b412-915f870dc038.jpg?v=1772019465","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-mpeg1-antibody-mpeg1-1-macrophage-expressed-gene-1-bha17136435","provider":"BioHippo","version":"1.0","type":"link"}