{"product_id":"zebrafish-msx1b-antibody-msxb-protein-bha17136392","title":"Zebrafish Msx1b Antibody \/ Msxb protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Msx1b Antibody \/ Msxb protein is a anti-MSX1B Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MSX1B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMsh homeobox 1b (Msx1b) is a transcription factor belonging to the muscle segment homeobox (Msx) gene family, which is involved in the regulation of developmental processes including cell proliferation, differentiation, and apoptosis. In zebrafish (Danio rerio), Msx1b plays a key role in craniofacial development, neural crest cell differentiation, and fin regeneration.\u003cp\u003eMsx1b is expressed during early embryogenesis in areas of active morphogenesis, such as the neural plate border, pharyngeal arches, and developing fin buds. It functions as a downstream effector of signaling pathways such as BMP, FGF, and Wnt, integrating these cues to regulate gene expression patterns during tissue patterning and regeneration. Notably, Msx1b expression is reactivated during appendage regeneration, making it a valuable marker for regenerative studies.\u003c\/p\u003e\n\u003cp\u003eZebrafish Msx1b is widely used in developmental biology to study neural crest cell fate, craniofacial patterning, and regenerative mechanisms, and provides a conserved model for understanding the genetic basis of congenital malformations and tissue repair.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MSX1B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MSX1B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MSX1B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MSX1B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MSX1B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327949165,"sku":"RZ1197","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c51c5d3c-0594-4bde-8636-7c2377cd1d6f.jpg?v=1772019454","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-msx1b-antibody-msxb-protein-bha17136392","provider":"BioHippo","version":"1.0","type":"link"}