{"product_id":"zebrafish-myca-antibody-myc-a-c-myc-a-bha17136436","title":"Zebrafish Myca Antibody \/ Myc-A \/ c-Myc-A","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Myca Antibody \/ Myc-A \/ c-Myc-A is a anti-Zebrafish Myca Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Zebrafish Myca\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTranscriptional regulator Myc A is a key member of the myelocytomatosis transcription factor family and plays a central role in controlling gene expression related to cell growth, proliferation, differentiation, and metabolism. In zebrafish, Myc A is an essential regulator during embryogenesis and is involved in the development of multiple organ systems.\u003cp\u003eMyc A functions by forming heterodimers with other transcriptional regulators and binding to specific DNA sequences to activate or repress target genes. It promotes the expression of genes involved in cell cycle progression, protein synthesis, and energy metabolism, while also modulating genes associated with apoptosis and cellular stress responses. This makes Myc A critical for balancing growth signals with environmental and developmental cues.\u003c\/p\u003e\n\u003cp\u003eDuring zebrafish development, Myc A is expressed in proliferative regions such as the brain, somites, and hematopoietic tissues. Its expression is tightly regulated to ensure proper tissue formation and to prevent excessive or disorganized cell growth. Dysregulation of Myc A can lead to developmental abnormalities and has been linked to tumor formation in zebrafish models, making it a valuable tool in cancer biology research.\u003c\/p\u003e\n\u003cp\u003eBecause of its strong conservation across vertebrates and its fundamental role in transcriptional control, zebrafish Myc A is widely used in studies of developmental genetics, stem cell function, oncogenesis, and metabolic regulation.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Zebrafish+Myca - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Zebrafish+Myca - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Zebrafish+Myca - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Zebrafish+Myca - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zebrafish+Myca+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328932205,"sku":"RZ1241","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3151fc46-3109-45c8-8fcf-acf25671bbd8.jpg?v=1772019462","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-myca-antibody-myc-a-c-myc-a-bha17136436","provider":"BioHippo","version":"1.0","type":"link"}