{"product_id":"zebrafish-otud5-antibody-otud5a-otud5b-bha17136452","title":"Zebrafish Otud5 Antibody \/ Otud5a \/ Otud5b","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Otud5 Antibody \/ Otud5a \/ Otud5b is a anti-OTUD5 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e OTUD5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eOtud5, or ovarian tumor domain containing protein five, is a deubiquitinating enzyme that regulates protein stability and cellular signaling by removing ubiquitin chains from target proteins. It is a member of the ovarian tumor domain protease family and plays an important role in controlling immune responses, chromatin structure, and transcriptional regulation.\u003cp\u003eIn zebrafish, Otud5 is expressed during early development and in various adult tissues, particularly in the nervous system, immune-related organs, and proliferative tissues. The zebrafish Otud5 protein is an ortholog of the human OTUD5 gene. Both proteins share conserved catalytic domains and regulatory motifs that are essential for deubiquitinase activity and interaction with signaling complexes.\u003c\/p\u003e\n\u003cp\u003eFunctionally, Otud5 acts as a negative regulator of immune signaling by deubiquitinating and stabilizing key proteins in pathways such as type one interferon and nuclear factor kappa B signaling. It also influences chromatin accessibility and transcription by regulating histone modifiers and chromatin remodelers. In humans, mutations in OTUD5 have been linked to developmental disorders involving intellectual disability and immune dysfunction.\u003c\/p\u003e\n\u003cp\u003eIn zebrafish, disruption of Otud5 function affects normal embryonic patterning and tissue development, suggesting a conserved role in regulating gene expression and cellular responses during growth and differentiation. Due to this conservation, zebrafish Otud5 is an important tool for modeling human disease mechanisms and studying deubiquitination in vertebrate development and immunity.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=OTUD5 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=OTUD5 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=OTUD5 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/OTUD5 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=OTUD5+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047330242925,"sku":"RZ1257","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_55a09d40-372f-4b81-b632-e9e94c63d27e.jpg?v=1772019467","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-otud5-antibody-otud5a-otud5b-bha17136452","provider":"BioHippo","version":"1.0","type":"link"}