{"product_id":"zebrafish-pa2g4-antibody-pa2g4a-pa2g4b-bha17136455","title":"Zebrafish Pa2g4 Antibody \/ Pa2g4a \/ Pa2g4b","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Pa2g4 Antibody \/ Pa2g4a \/ Pa2g4b is a anti-PA2G4 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasmic, Nuclear (human similarity).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PA2G4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eProliferation-associated 2G4, also known as Pa2g4, is a key protein involved in regulating several fundamental cellular processes, including cell cycle progression, apoptosis, and transcriptional regulation. It is a member of the pentraxin family of proteins, which are important in immune modulation and inflammatory responses. Pa2g4 functions to ensure the proper regulation of cell survival and proliferation, particularly during embryonic development and under cellular stress conditions.\u003cp\u003eIn zebrafish, Pa2g4 is an ortholog of the human PA2G4 gene. Both zebrafish and human Pa2g4 proteins share conserved functional domains, including the pentraxin domain, which is involved in protein-protein interactions and modulation of inflammatory signaling pathways. The functional similarity between the zebrafish and human versions of Pa2g4 makes the zebrafish model particularly useful for studying the roles of Pa2g4 in cellular growth, immune responses, and disease modeling.\u003c\/p\u003e\n\u003cp\u003eIn addition to its role in regulating the cell cycle, Pa2g4 is involved in the stress response by influencing pathways that govern cell survival and apoptosis. Pa2g4 interacts with various cell cycle regulators such as cyclins and cyclin-dependent kinases to modulate cell cycle progression and ensure proper timing of cellular events. Moreover, Pa2g4 is essential in immune cell function by regulating the activation and proliferation of immune cells during inflammatory conditions.\u003c\/p\u003e\n\u003cp\u003ePa2g4 is expressed in several tissues in zebrafish, including the brain, heart, and liver, and plays a crucial role during early embryogenesis. It is involved in developmental processes such as neurogenesis, organogenesis, and cell differentiation. Pa2g4 is also important for maintaining tissue homeostasis, and its regulation ensures normal tissue repair and regenerative processes.\u003c\/p\u003e\n\u003cp\u003eBecause of its evolutionary conservation and involvement in key biological pathways, zebrafish Pa2g4 is a valuable model for studying developmental biology, cancer research, immunology, and cell cycle regulation.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PA2G4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PA2G4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PA2G4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PA2G4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PA2G4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047330210157,"sku":"RZ1260","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1747eb4d-2373-4cea-8298-532e85450532.jpg?v=1772019468","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-pa2g4-antibody-pa2g4a-pa2g4b-bha17136455","provider":"BioHippo","version":"1.0","type":"link"}