{"product_id":"zebrafish-phyhipl-antibody-phyhiplb-phytanoyl-coa-hydroxylase-interacting-protein-like-bha17136464","title":"Zebrafish Phyhipl Antibody \/ Phyhiplb \/ Phytanoyl-CoA hydroxylase-interacting protein-like","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Phyhipl Antibody \/ Phyhiplb \/ Phytanoyl-CoA hydroxylase-interacting protein-like is a anti-Zebrafish Phyhipl Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Zebrafish Phyhipl\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePhyhipl (PH domain and IF2-like domain containing protein) is a protein involved in cellular processes such as signal transduction, cellular stress response, and regulation of transcription. It is characterized by the presence of the PH domain, which is involved in binding to phosphoinositides and other lipid signals, and the IF2-like domain, which may play a role in protein-protein interactions and cellular signaling pathways. Phyhipl is involved in regulating key processes such as cell cycle progression, cell growth, and cell differentiation.\u003cp\u003eIn zebrafish, Phyhipl is an ortholog of the human PHYHIPL gene. Both zebrafish and human Phyhipl share high sequence similarity, particularly in the PH domain and IF2-like domain, suggesting conservation of function across species. This conservation makes zebrafish an excellent model for studying the molecular functions of Phyhipl and its involvement in cellular signaling and developmental processes.\u003c\/p\u003e\n\u003cp\u003ePhyhipl is thought to play a role in the regulation of cellular stress responses, especially under conditions of oxidative stress or hypoxia, by modulating cellular signaling networks. It may also interact with cellular scaffolding proteins and signal transduction pathways, helping to coordinate responses to environmental and internal cellular stresses. This protein is likely involved in neural development, embryonic development, and organogenesis, particularly in the brain, heart, and muscle, where regulation of cell growth and differentiation is crucial.\u003c\/p\u003e\n\u003cp\u003eZebrafish Phyhipl has isoforms, which may vary in their domain structure, tissue-specific expression, and functional capacity. The isoforms could be differentially expressed in various tissues, reflecting the need for fine-tuned regulation in response to changing environmental and metabolic conditions. Isoform variation is likely important for tissue-specific functions during development and tissue regeneration.\u003c\/p\u003e\n\u003cp\u003eGiven its essential role in signal transduction, cell stress responses, and developmental regulation, zebrafish Phyhipl is an important model for investigating the molecular mechanisms underlying cellular stress responses, neurodevelopmental diseases, and cancer. Its functional conservation with the human protein makes it a valuable tool for studying human diseases that involve cellular signaling and developmental defects.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Zebrafish+Phyhipl - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Zebrafish+Phyhipl - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Zebrafish+Phyhipl - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Zebrafish+Phyhipl - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zebrafish+Phyhipl+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047331029357,"sku":"RZ1269","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2161324b-564b-45f6-89e4-d41b4f9879b2.jpg?v=1772019468","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-phyhipl-antibody-phyhiplb-phytanoyl-coa-hydroxylase-interacting-protein-like-bha17136464","provider":"BioHippo","version":"1.0","type":"link"}