{"product_id":"zebrafish-ppp3r1-antibody-ppp3r1a-ppp3r1b-bha17136473","title":"Zebrafish Ppp3r1 Antibody \/ Ppp3r1a \/ Ppp3r1b","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Ppp3r1 Antibody \/ Ppp3r1a \/ Ppp3r1b is a anti-PPP3R1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PPP3R1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePpp3r1 (Protein phosphatase 3 regulatory subunit 1), also known as PP2B regulatory subunit, is a critical protein involved in the regulation of calcium-dependent signaling pathways. It functions as a regulatory subunit for the protein phosphatase 3 (PP3), also known as calcineurin, a serine\/threonine phosphatase that plays a significant role in regulating immune responses, neural development, and cardiac function. Ppp3r1 interacts with calcineurin to modulate its phosphatase activity, influencing various cellular processes, including transcription, protein synthesis, and cellular differentiation.\u003cp\u003eIn zebrafish, Ppp3r1 is an ortholog of the human PPP3R1 gene. The zebrafish and human versions of Ppp3r1 exhibit significant sequence conservation, especially in regions that are essential for interaction with calcineurin. This conservation suggests that Ppp3r1 in zebrafish performs similar regulatory functions as its human counterpart in calcium-mediated signaling and cellular processes. The zebrafish model is particularly useful for studying calcium signaling, immune regulation, and neural and cardiac development.\u003c\/p\u003e\n\u003cp\u003eZebrafish Ppp3r1 may also have isoforms, which are generated through alternative splicing. These isoforms could exhibit tissue-specific expression and play distinct roles in regulating calcineurin activity in different physiological conditions or during developmental stages. Isoform diversity may allow for fine-tuned regulation of calcineurin signaling in response to various cellular and environmental cues.\u003c\/p\u003e\n\u003cp\u003eIn zebrafish, Ppp3r1 is widely expressed in neural tissues, cardiac cells, and immune cells, reflecting its essential roles in neural development, immune responses, and cardiac function. Its involvement in calcineurin activation plays a pivotal role in regulating gene expression and cell differentiation. Disruption of Ppp3r1 or calcineurin signaling in zebrafish can lead to defects in neural patterning, immune response modulation, and cardiac development, providing a valuable model for studying diseases related to abnormal calcium signaling, such as cardiovascular diseases, neurodegenerative disorders, and autoimmune diseases.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PPP3R1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PPP3R1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PPP3R1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PPP3R1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PPP3R1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047330505069,"sku":"RZ1278","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d84a3b5b-909a-45e5-a40d-fb28e972be3f.jpg?v=1772019470","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-ppp3r1-antibody-ppp3r1a-ppp3r1b-bha17136473","provider":"BioHippo","version":"1.0","type":"link"}