{"product_id":"zebrafish-psmd7-antibody-26s-proteasome-non-atpase-regulatory-subunit-7-bha17136490","title":"Zebrafish Psmd7 Antibody \/ 26S proteasome non-ATPase regulatory subunit 7","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Psmd7 Antibody \/ 26S proteasome non-ATPase regulatory subunit 7 is a anti-PSMD7 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PSMD7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePsmd7 (Proteasome 26S subunit, non-ATPase 7) is an important component of the 19S regulatory particle of the 26S proteasome, which is responsible for the ATP-dependent degradation of ubiquitinated proteins. As part of the proteasome complex, Psmd7 contributes to the recognition, unfolding, and translocation of substrates into the 20S catalytic core where they are degraded. This process is essential for cellular homeostasis, regulation of the cell cycle, and the maintenance of protein integrity by ensuring the timely degradation of damaged, misfolded, or excess proteins.\u003cp\u003eIn zebrafish, Psmd7 is the ortholog of the human PSMD7 gene, sharing a high degree of sequence similarity and functional conservation. The zebrafish and human versions of Psmd7 contain similar domains that allow interaction with other proteasomal subunits, enabling the proper assembly and function of the 26S proteasome complex. This functional conservation underscores the relevance of zebrafish as a model organism for studying proteasomal processes and their role in human health.\u003c\/p\u003e\n\u003cp\u003ePsmd7 in zebrafish may have isoforms resulting from alternative splicing, although specific isoforms may not be fully characterized. These isoforms could play roles in different tissues or developmental stages, contributing to the fine-tuning of proteasomal activity. Isoform variation could also provide differential regulation of proteasome function in response to environmental stress, cellular signaling, or developmental needs.\u003c\/p\u003e\n\u003cp\u003eIn zebrafish, Psmd7 is expressed in a variety of tissues, especially those with high protein turnover, such as the brain, liver, and kidney. This expression pattern reflects the protein's essential role in controlling protein degradation, supporting cellular functions such as stress response, apoptosis, and differentiation.\u003c\/p\u003e\n\u003cp\u003eGiven the high conservation between zebrafish Psmd7 and human PSMD7, the zebrafish model is valuable for studying proteasomal dysfunctions that contribute to diseases in humans, such as cancer, neurodegenerative disorders, and immune dysfunctions. Disruption in PSMD7 has been linked to altered proteasomal activity, which can lead to the accumulation of damaged proteins and cellular stress. The zebrafish model can be used to explore potential therapeutic approaches aimed at modulating proteasomal function and preventing the pathological effects associated with these diseases.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PSMD7 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PSMD7 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PSMD7 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PSMD7 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PSMD7+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047331520877,"sku":"RZ1295","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d8a62576-21fa-44c7-a60c-493406ea1eca.jpg?v=1772019471","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-psmd7-antibody-26s-proteasome-non-atpase-regulatory-subunit-7-bha17136490","provider":"BioHippo","version":"1.0","type":"link"}