{"product_id":"zebrafish-rcc2-antibody-protein-rcc2-homolog-bha17136498","title":"Zebrafish Rcc2 Antibody \/ Protein RCC2 homolog","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Rcc2 Antibody \/ Protein RCC2 homolog is a anti-RCC2 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasm, cell membrane, nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RCC2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eZebrafish Rcc2, known as regulator of chromosome condensation 2, is a multifunctional protein that plays a role in cell cycle progression, cytoskeletal dynamics, and cellular signaling. It is particularly involved in mitotic events, where it regulates processes related to chromosome condensation and segregation. Rcc2 is also known to interact with small GTP binding proteins such as Rac1, thereby influencing cell migration, adhesion, and actin cytoskeleton organization.\u003cp\u003eZebrafish Rcc2 is an ortholog of the human RCC2 protein and shares significant sequence and functional similarity. In both species, Rcc2 functions as part of the chromosomal passenger complex and contributes to the accurate distribution of chromosomes during mitosis. Disruption of Rcc2 function can impair cell division and affect developmental processes, making it a key protein for studies of cell proliferation and morphogenesis.\u003c\/p\u003e\n\u003cp\u003eResearch on zebrafish Rcc2 is valuable for understanding its conserved roles in cell cycle regulation and cytoskeletal rearrangements. Zebrafish models allow for the exploration of Rcc2 function during embryogenesis, where rapid and precise cell division is essential for normal development.\u003c\/p\u003e\n\u003cp\u003eAntibodies targeting zebrafish Rcc2 protein are important tools for studying mitosis, cytoskeletal organization, and related signaling pathways. The orthology between zebrafish Rcc2 and human RCC2 supports the use of zebrafish as a model to investigate fundamental mechanisms of cell division and to study pathways that may be altered in diseases such as cancer.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RCC2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RCC2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RCC2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RCC2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RCC2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047331127661,"sku":"RZ1303","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7634b881-c443-4ce9-9604-46b77694c711.jpg?v=1772019475","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-rcc2-antibody-protein-rcc2-homolog-bha17136498","provider":"BioHippo","version":"1.0","type":"link"}