{"product_id":"zebrafish-sod1-antibody-superoxide-dismutase-1-bha17136506","title":"Zebrafish Sod1 Antibody \/ Superoxide dismutase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Sod1 Antibody \/ Superoxide dismutase 1 is a anti-SOD1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SOD1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eZebrafish Sod1, also known as superoxide dismutase 1, is a critical antioxidant enzyme that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen. This enzymatic activity is essential for protecting cells from oxidative damage caused by reactive oxygen species, which are byproducts of normal cellular metabolism and environmental stress. Sod1 plays a vital role in maintaining redox balance, protecting cellular structures, and supporting overall cellular homeostasis.\u003cp\u003eZebrafish Sod1 is an ortholog of the human SOD1 protein, sharing high sequence and functional conservation. Mutations in human SOD1 are well known for their link to amyotrophic lateral sclerosis (ALS), and zebrafish models expressing mutant Sod1 have been used extensively to study the mechanisms of neurodegeneration and oxidative stress. The conserved enzymatic function of Sod1 in zebrafish makes it a powerful model for investigating oxidative damage, neuronal health, and stress response pathways.\u003c\/p\u003e\n\u003cp\u003eThere are no confirmed isoforms of zebrafish Sod1. The protein is expressed broadly in various tissues, with higher expression in metabolically active organs such as the brain, liver, and muscles where reactive oxygen species production is elevated. Its activity is tightly regulated, as both deficient and excessive reactive oxygen species can lead to cellular dysfunction.\u003c\/p\u003e\n\u003cp\u003eAntibodies targeting zebrafish Sod1 protein are important tools for studying oxidative stress pathways, mitochondrial function, and the effects of environmental or chemical stressors on cellular health. These antibodies are commonly used in applications such as western blot, immunohistochemistry, immunofluorescence, and ELISA to analyze Sod1 expression and regulation in zebrafish tissues.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SOD1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SOD1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SOD1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SOD1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SOD1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047331488109,"sku":"RZ1311","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_11a86f1e-beed-4fdd-b371-10aa912c0c5b.jpg?v=1772019475","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-sod1-antibody-superoxide-dismutase-1-bha17136506","provider":"BioHippo","version":"1.0","type":"link"}