{"product_id":"zebrafish-sod2-antibody-superoxide-dismutase-2-bha17136507","title":"Zebrafish Sod2 Antibody \/ Superoxide dismutase 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Sod2 Antibody \/ Superoxide dismutase 2 is a anti-SOD2 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SOD2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eZebrafish Sod2, also known as superoxide dismutase 2, is a manganese containing antioxidant enzyme located in the mitochondrial matrix. It catalyzes the dismutation of superoxide radicals into hydrogen peroxide and oxygen, which is a critical step in defending cells against oxidative stress generated during mitochondrial respiration. Sod2 is essential for maintaining mitochondrial integrity, reducing oxidative damage to proteins, lipids, and DNA, and ensuring proper cellular metabolism and survival.\u003cp\u003eZebrafish Sod2 is an ortholog of the human SOD2 protein, with strong sequence and functional conservation. As in humans, Sod2 in zebrafish plays a vital role in protecting highly metabolic tissues such as the brain, heart, and muscles from oxidative damage. Mutations or reduced activity of Sod2 can lead to mitochondrial dysfunction and oxidative stress, contributing to developmental abnormalities and degenerative diseases.\u003c\/p\u003e\n\u003cp\u003eCurrently, there are no confirmed isoforms of zebrafish Sod2. It is broadly expressed across tissues but is particularly abundant in cells with high energy demands. Zebrafish models deficient in Sod2 have been used to investigate the consequences of oxidative imbalance and to explore therapeutic approaches aimed at reducing mitochondrial stress.\u003c\/p\u003e\n\u003cp\u003eAntibodies targeting zebrafish Sod2 protein are important tools for studying mitochondrial antioxidant defense systems, oxidative signaling pathways, and stress responses. These antibodies can be utilized in western blot, immunohistochemistry, immunofluorescence, and ELISA to monitor Sod2 levels and localization in zebrafish tissues.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SOD2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SOD2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SOD2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SOD2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SOD2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047331684717,"sku":"RZ1312","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fab1ffcf-351f-423f-a92c-ce32e59b1ea2.jpg?v=1772019475","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-sod2-antibody-superoxide-dismutase-2-bha17136507","provider":"BioHippo","version":"1.0","type":"link"}