{"product_id":"zebrafish-star-antibody-steroidogenic-acute-regulatory-protein-bha17136512","title":"Zebrafish Star Antibody \/ Steroidogenic acute regulatory protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Star Antibody \/ Steroidogenic acute regulatory protein is a anti-Zebrafish Star Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Zebrafish Star\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eZebrafish Star, also known as steroidogenic acute regulatory protein, is a key mitochondrial protein involved in the transport of cholesterol from the outer to the inner mitochondrial membrane. This transport step is essential for the initiation of steroid hormone biosynthesis. By facilitating cholesterol delivery to the cytochrome P450 enzyme system, Star regulates the production of hormones such as cortisol, estrogen, and testosterone. In zebrafish, Star is crucial for the development and function of steroidogenic tissues, including the gonads and interrenal gland.\u003cp\u003eZebrafish Star is an ortholog of the human STAR protein, with strong sequence and functional conservation across vertebrates. As in humans, zebrafish Star plays a vital role in maintaining proper hormone synthesis and reproductive health. Disruption of Star function can lead to impaired steroidogenesis and developmental abnormalities, making it an important focus for research on endocrine system regulation.\u003c\/p\u003e\n\u003cp\u003eThe use of a Zebrafish Star antibody allows scientists to study the expression and localization of Star in various tissues during development and under experimental conditions. Such antibodies are valuable for applications like western blot, immunohistochemistry, and immunofluorescence, providing insights into how Star activity influences hormone production. A Zebrafish Star antibody is also useful for investigating the effects of environmental stressors or chemical modulators on steroid biosynthesis.\u003c\/p\u003e\n\u003cp\u003eThere are no reported isoforms of zebrafish Star. Due to the high degree of conservation between zebrafish Star and its human counterpart, findings obtained with a Zebrafish Star antibody can be applied to understanding steroidogenesis in human health and disease.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Zebrafish+Star - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Zebrafish+Star - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Zebrafish+Star - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Zebrafish+Star - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zebrafish+Star+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047331619181,"sku":"RZ1317","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b7424c08-2064-4667-9e93-207fd9d41dac.jpg?v=1772019475","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-star-antibody-steroidogenic-acute-regulatory-protein-bha17136512","provider":"BioHippo","version":"1.0","type":"link"}