{"product_id":"zebrafish-tfap2a-antibody-ap2-alpha-bha17136385","title":"Zebrafish Tfap2a Antibody \/ Ap2 alpha","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Tfap2a Antibody \/ Ap2 alpha is a anti-TFAP2A Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TFAP2A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTranscription factor AP-2 alpha (Tfap2a) is a DNA-binding transcription factor that plays a critical role in embryonic development by regulating genes involved in cell fate determination, proliferation, and differentiation. In zebrafish (Danio rerio), Tfap2a is essential for the proper development of the neural crest, craniofacial structures, epidermis, and parts of the central nervous system.\u003cp\u003eTfap2a is expressed early in development, particularly in the neural plate border and migrating neural crest cells. It functions by activating or repressing target genes involved in ectodermal and neural crest lineage specification. Loss-of-function studies in zebrafish have demonstrated that tfap2a is required for cranial neural crest formation, melanocyte differentiation, and proper facial cartilage patterning.\u003c\/p\u003e\n\u003cp\u003eGiven its high degree of conservation and developmental importance, zebrafish Tfap2a is widely used as a model to study craniofacial anomalies, neural crest biology, and transcriptional regulation during vertebrate embryogenesis. It is also a valuable marker for identifying early ectodermal and neural crest derivatives.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TFAP2A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TFAP2A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TFAP2A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TFAP2A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TFAP2A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327981933,"sku":"RZ1190","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5c4633a4-41cd-42f1-a9b3-8d8d4e06a67b.jpg?v=1772019454","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-tfap2a-antibody-ap2-alpha-bha17136385","provider":"BioHippo","version":"1.0","type":"link"}