{"product_id":"zebrafish-xpo1-antibody-xpo1a-xpo1b-exportin-1-bha17136518","title":"Zebrafish Xpo1 Antibody \/ Xpo1a \/ Xpo1b \/ Exportin 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Xpo1 Antibody \/ Xpo1a \/ Xpo1b \/ Exportin 1 is a anti-XPO1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e XPO1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eZebrafish Xpo1, also known as Exportin 1, is a critical protein involved in the nuclear export of cargo molecules, including RNA and ribosomal proteins. Xpo1 functions as a transport receptor that mediates the export of proteins and RNA from the nucleus to the cytoplasm by recognizing cargo molecules and facilitating their passage through the nuclear pore complex. This process is essential for regulating gene expression, RNA processing, and cellular signaling, as it ensures that molecules required for various cellular processes are efficiently transported to the appropriate cellular compartments.\u003cp\u003eZebrafish Xpo1 is an ortholog of the human XPO1 protein, and the two share significant sequence and functional conservation. Similar to human Xpo1, zebrafish Xpo1 is involved in the transport of a wide variety of cargo molecules, including ribosomal subunits and RNA species such as mRNA, tRNA, and snRNA. This makes Xpo1 essential for cellular homeostasis and the proper functioning of many cellular systems, including gene expression, protein synthesis, and stress responses.\u003c\/p\u003e\n\u003cp\u003eZebrafish Xpo1 exists in multiple isoforms, which may have specialized roles in different tissues or developmental stages. The primary isoform is responsible for most of the transport activity, while other isoforms may be involved in specific cargo recognition or subcellular localization. The diversity of Xpo1 isoforms allows for fine-tuned regulation of nuclear export and contributes to the adaptability of the cellular transport system in zebrafish.\u003c\/p\u003e\n\u003cp\u003eThe use of a Zebrafish Xpo1 antibody allows researchers to study the expression, localization, and function of Xpo1 during various stages of zebrafish development. Zebrafish Xpo1 antibody reagents are essential tools for applications such as western blot, immunohistochemistry, immunofluorescence, and ELISA, enabling the detection and analysis of Xpo1 isoforms and their involvement in nuclear export pathways. A Zebrafish Xpo1 antibody can help identify how perturbations in Xpo1 function affect cellular processes like mRNA transport, protein synthesis, and cell signaling.\u003c\/p\u003e\n\u003cp\u003eBy using a high-quality Zebrafish Xpo1 antibody, scientists can gain insights into the regulation of nuclear-cytoplasmic transport, a crucial aspect of cellular function that is conserved across species.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=XPO1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=XPO1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=XPO1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/XPO1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=XPO1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047331979629,"sku":"RZ1324","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6f817648-2829-4f23-aeee-18edad0b54a8.jpg?v=1772019476","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-xpo1-antibody-xpo1a-xpo1b-exportin-1-bha17136518","provider":"BioHippo","version":"1.0","type":"link"}