{"product_id":"zinc9315614-bhb21300385","title":"ZINC9315614","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl-5-nitrothiophene-2-carboxamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e ZINC09315614, Z26888283, N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl-5-nitrothiophene-2-carboxamide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 17392877\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C13H10ClFN2O3S.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e P2X7 receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e ZINC9315614 is a novel antagonist of the purinergic P2X7 receptors, shown to inhibit YoPro1 uptake and BzATP-induced Ca2+ responses in HEK-hP2X7 cells with IC50 of 0.8 µM and 3.2 µM, respectively1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e ZINC09315614, Z26888283, N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl-5-nitrothiophene-2-carboxamide\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eZINC9315614 is a selective antagonist of purinergic P2X7 receptors. It binds to the ATP-binding pocket of P2X71. ZINC9315614 inhibits YoPro1 dye uptake and BzATP-induced Ca2+ responses in HEK-human P2X7 cells with IC50 value of 0.8 µM and 3.2 µM, respectively1.P2X receptors are cationic trimeric channel complexes that function as ATP-gated calcium-permeable and are considered to be an attractive therapeutic target. This family contains seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in various cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors can be found in almost all tissues1,2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249715274093,"sku":"Z-145-10MG-1","price":109.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311581585773,"sku":"Z-145-25MG-1","price":220.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311581618541,"sku":"Z-145-5MG-1","price":79.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311581651309,"sku":"Z-145-50MG-1","price":357.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Z-145_gr.gif?v=1778544459","url":"https:\/\/www.ebiohippo.com\/products\/zinc9315614-bhb21300385","provider":"BioHippo","version":"1.0","type":"link"}