{"product_id":"znrd2-antibody-zinc-ribbon-domain-containing-protein-2-sssca1-bha17135979","title":"ZNRD2 Antibody \/ Zinc ribbon domain-containing protein 2 \/ SSSCA1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZNRD2 Antibody \/ Zinc ribbon domain-containing protein 2 \/ SSSCA1 is a anti-ZNRD2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ZNRD2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eZNRD2 antibody detects Zinc ribbon domain-containing protein 2, a nuclear factor involved in RNA polymerase I transcription and nucleolar organization. The UniProt recommended name is Zinc ribbon domain-containing protein 2 (ZNRD2), also known as Sjogren syndrome\/scleroderma autoantigen 1 (SSSCA1). This small zinc-binding protein associates with chromatin and nuclear scaffolds, contributing to transcriptional regulation and RNA processing.\u003cbr\u003e\u003cbr\u003eFunctionally, ZNRD2 antibody identifies a 179-amino-acid nuclear protein containing a C2H2-type zinc ribbon domain that facilitates nucleic acid and protein interactions. ZNRD2 plays a role in ribosomal RNA synthesis by modulating RNA polymerase I activity within the nucleolus. It interacts with components of the transcriptional machinery, linking chromatin structure to gene expression.\u003cbr\u003e\u003cbr\u003eThe ZNRD2 gene is located on chromosome 6p21.33 within the major histocompatibility complex (MHC) region, reflecting its immunological relevance. It is expressed in a variety of tissues, including thymus, spleen, and epithelial cells. ZNRD2 has been identified as an autoantigen in autoimmune disorders such as Sjogren syndrome and scleroderma, where antibodies against SSSCA1 epitopes are frequently detected.\u003cbr\u003e\u003cbr\u003ePathologically, aberrant ZNRD2 expression has been associated with cancer and autoimmunity. Its altered transcriptional activity may contribute to abnormal cell proliferation and immune dysregulation. Because ZNRD2 participates in ribosome biogenesis and nuclear organization, its dysfunction can influence cellular growth and stress responses.\u003cbr\u003e\u003cbr\u003eZNRD2 antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence to study nucleolar structure, RNA synthesis, and autoantigen profiles. \u003cbr\u003e\u003cbr\u003eStructurally, ZNRD2 consists of an N-terminal zinc ribbon domain responsible for nucleic acid binding and a conserved C-terminal tail that interacts with nuclear proteins. This antibody helps elucidate ZNRD2's functions in chromatin-associated transcription and its role as an autoimmune target in connective tissue diseases.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ZNRD2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ZNRD2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ZNRD2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ZNRD2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ZNRD2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047311335789,"sku":"FY13077","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2823a787-b31c-41d1-ab21-def0b6a1c2b8.jpg?v=1772019425","url":"https:\/\/www.ebiohippo.com\/products\/znrd2-antibody-zinc-ribbon-domain-containing-protein-2-sssca1-bha17135979","provider":"BioHippo","version":"1.0","type":"link"}