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ATF4 (Activating Transcription Factor 4) Gene

Published On 11/13/2019 3:41 PM

ATF4  (Activating Transcription Factor 4) 

Gene and Protein Information   (UniProtKB/Swiss-Prot)

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088). ATF4_HUMAN,P18848
 
Alternate names for ATF4 Gene
 
 
 
Additional gene information for ATF4 Gene

 
HGNC: 786  Entrez Gene: 468  Ensembl: ENSG00000128272  OMIM: 604064  UniProtKB: P18848
  
Gene Wiki entry for ATF4 Gene

ATF4 Gene Function 

See 300 articles about ATF4 gene function at PubMed  

Understanding of the functional role (s) of the Activating Transcription Factor 4 (ATF4) in HIV regulation and production
ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres
 Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis
Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response
ATF4 gene network mediates cellular response to the anticancer PAD inhibitor YW3-56 in triple-negative breast cancer cells
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia



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Protein Products  LOAD MORE
 

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Assay Products  LOAD MORE

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This entry was posted in Gene Database

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