Complex structures and high production costs associated withmonoclonal antibodies (mAbs) have limited their achievable clinical applications. For this reason, scientists focusing on antibody drug discovery have shifted their interests toward recombinant antibody fragments.
Recombinant antibodies, such as single domain antibodies (sdAb), are a new generation of engineered antibody fragment that consisted of a single monomeric variable antibody domain. sdAb is derived from camelid heavy chain antibodies which lack the light chain and CH domain of the heavy chain in the conventional Fab region. Therefore sdAb is smaller, more soluble and has higher stabilities than conventional antibody. sdAb also features higher permeability, lower immunogenicity and both simple and cost-effective production procedures. These advantages have made it possible for sdAb to have a broader range of applications within the biotechnology, pharmaceutical and immuno-therapeutic industries.
Based on Synbio Technologies’ extensive expertise in sdAb and advanced sdAb discovery technology, we can provide our customers with a comprehensive one stop solution from antigen production to specific recombinant sdAb expression.
Camel immunization (eg. dromedaries, camels, llamas, and alpacas)
A glycerol stock of sdAb expressing bacteria (TG1)
Phage-displayed sdAb library
Top 5 identified sdAb strain and corresponding sequences
Full reports (PDF)
10 – 11 Months
PBMC isolation & immune library construction
Screening of phage-displayed library
Functional assay for sdAb
Large scale sdAb expression by yeast (followed by properties identification)
If you have any questions, please feel free to contact us for assistance during business hours. Our experienced project managers will provide you with professional support to ensure the success of your project.
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