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Hif1a-Flox

SKU : BHAM00137

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-190065
Description	Model Description: These mice carry loxP sites flanking exon 2 of Hif1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hif1a gene. Official Symbol: Hif1a NCBI ID: 15251 MGI ID: 106918 Ensembl ID: ENSMUSG00000021109 Pubmed: Hif1a Human Ortholog: HIF1A
Nomenclature	C57BL/6JSmoc-Hif1a^{tm1(flox)Smoc}
Exon	Exon 2
Application	Hypoxia-Inducible Factor 1-Alpha,Metabolism And Cancer Research
Disease	Von Hippel-Lindau Disease
Disease	Cardio-metabolic Disease
KI/KO Gene	Hif1a
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Vhl-Flox(2)(NM-CKO-200232) and Pck1-cre mice.
Synonyms	MOP1, bHLHe78, AA959795, HIF1alpha, HIF1-alpha, HIF-1-alpha

Reference	MGI:6189180 Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH, Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72

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