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Hnf4a-Flox

SKU : BHAM00134

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-190062
Description	Model Description: These Hnf4a flox mice possess loxP sites flanking exon 2. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene. Official Symbol: Hnf4a NCBI ID: 15378 MGI ID: 109128 Ensembl ID: ENSMUSG00000017950 Pubmed: Hnf4a Human Ortholog: HNF4A
Nomenclature	C57BL/6JSmoc-Hnf4a^{tm1(flox)Smoc}
Exon	Exon 2.
Application	Transcriptional Regulator, Insulin Secretion Related
Disease	Fanconi Syndrome
Disease	Cardio-metabolic Disease
KI/KO Gene	Hnf4a
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Six2-cre mice.
Synonyms	Hnf4, HNF-4, MODY1, Nr2a1, Tcf14, TCF-14, Hnf4alpha

Reference	Marable SS, Chung E, Adam M, Potter SS, Park JS, Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI Insight. 2018 Jul 25;3(14)

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