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Lepr-KO

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KO-190663
Description	Model Description: Exon 5 of Lepr gene was deleted to generate Lepr knockout mice. Official Symbol: Lepr NCBI ID: 16847 MGI ID: 104993 Ensembl ID: ENSMUSG00000057722 Pubmed: Lepr Human Ortholog: LEPR
Nomenclature	C57BL/6JSmoc-Lepr^em1Smoc
Exon	Exon 5
Application	Obesity
Disease	Type 2 Diabetes Mellitus
Disease	Cardio-metabolic Disease
KI/KO Gene	Lepr
Synonyms	db, Obr, obl, Leprb, Modb1, LEPROT, OB-RGRP, diabetes, obese-like

Reference	Lee Y, Berglund ED, Yu X, Wang MY, Evans MR, Scherer PE, Holland WL, Charron MJ, Roth MG, Unger RH, Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13217-22

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