The study found key factors that promote the development of neurodegenerative diseases such as Alzheimer's disease

Copyright © iCell Bioscience Inc, Shanghai 2018-2019

The normal function of human cells is in the form of the need for the synergy of organelles. In many cases, damage to the communication between organelles can lead to the appearance of a stress response.

Recently, researchers from Basel University have discovered a key factor in promoting the development of neurodegenerative diseases such as Alzheimer's disease. Such cytokines are produced by the stress response of intracellular mitochondria.

Researchers have discovered the mechanisms of damage responses in brain neurons. Chronic stress in cells has an important impact on the development of neurodegenerative diseases. These neuroscientists have found that damage to mitochondrial function leads to successive damage to the function of the surrounding organelles, leading to the release of the stress response factor "FGF21" and to mitochondrial damage.

The researchers further found that this damage also occurs during the development of neurodegenerative diseases and occurs before the death of neurons.

FGF21 is an important molecular marker for the early diagnosis of diseases such as Alzheimer's disease and Parkinson's disease. However, since FGF21 can also be secreted by other tissues, such as liver and adipose tissue, further stricter tests are needed. In summary, the discovery of such novel biomarkers suggests that neuroprotective effects can be achieved by targeting chronic cell damage.