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SNCA (Synuclein Alpha)

Published On 11/12/2019 6:39 PM
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SNCA (Synuclein Alpha) 
Gene and Protein Information   (UniProtKB/Swiss-Prot
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion, and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca (2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein Receptors) at the presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). SYUA_HUMAN,P37840
 
Alternate names for SNCA Gene
 
 
 
Additional gene information for SNCA Gene
   

 
Gene Wiki entry for SNCA Gene
 
Antibody Products Load More
 
Anti-Synuclein-Α Antibody Unconjugated BHA10301370
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SNCA Antibody, FITC Conjugated
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Anti-SNCA Antibody
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SNCA Antibody
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Protein Products  LOAD MORE
 
Alpha Synuclein A30P/A53T Human Recombinant
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Alpha Synuclein Delta-NAC Human Recombinant
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Recombinant Synuclein Alpha (SNCa)
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Alpha Synuclein Protein
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Assay Products  LOAD MORE
Porcine Alpha-Synuclein,SNCA ELISA Kit
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SKU :BHE12110804
 
SNCa ELISA Kit BHE10805917
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Human Alpha-Synuclein,SNCA ELISA Kit
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ELISA Kit For Pig Alpha-Synuclein
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ELISA Kit For Rat Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1
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Synuclein Alpha ELISA Kit BHE10103624
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Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) Oligomer (SNCA Oligomer) ELISA Kit
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SNCA ELISA Kit BHE10800251
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Synuclein Alpha ELISA Kit BHE10103622
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This entry was posted in Gene Database

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