◆ ISO Certified Quality
RNA QC Standards
High-quality RNA reference materials produced under strict quality management systems. HPLC-verified with comprehensive COA documentation for assay validation and routine quality control.
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HPLC ✓
COA ✓
Quality Assurance
At-a-Glance
Our RNA QC standards are manufactured under ISO-compliant quality systems, providing reliable reference materials for your critical assays and regulatory submissions.
Consistent Quality
Strict quality control and HPLC analysis ensure batch-to-batch consistency for your QC workflows and long-term studies.
Flexible Design
Choose from existing reference sequences or request custom standards tailored to your specific assay design and readout requirements.
Regulatory Support
Comprehensive documentation including COA and QC data supports method validation and regulatory submissions in diagnostics.
100%
HPLC Checked
COA
Default Included
Multiple
Lengths & Formats
GMP
Grade Available
QC Methods & Detection
Multi-platform analytical verification ensuring the highest quality standards for your RNA reference materials.
HPLC Analysis
High-Performance Liquid Chromatography for every lot. Primary method for purity assessment and quantitative analysis of RNA oligonucleotides.
Purity ≥95%
Quantitative
Mass Spectrometry
ESI-MS verification for molecular weight confirmation and sequence integrity validation.
MW Accuracy
±0.01%
PAGE Analysis
Polyacrylamide Gel Electrophoresis for size verification and detection of deletion sequences or impurities.
Size Resolution
Single nt
Endotoxin Testing
LAL chromogenic endpoint assay for bacterial endotoxin detection, critical for cell-based assays and therapeutic applications.
<0.1 EU/μg
LAL Tested
Detection Sensitivity Comparison
Purity Grade Standards
Three quality tiers designed to match your application requirements, from research to clinical development.
Feature
Research
Preclinical
GMP
HPLC Purity
≥95%
≥98%
≥99%
Mass Spec Verification
✓
✓
✓
Endotoxin Testing
—
✓
✓
Batch Consistency
Standard
High
Validated
Documentation
COA
Extended COA
Full DMF
Research Grade
Discovery & Screening
Ideal for initial assay development and routine laboratory use.
- Assay optimization
- Pilot studies
- Method validation
Preclinical Grade
IND-Enabling Studies
Enhanced QC for toxicology and pharmacology studies.
- Animal studies
- Stability testing
- Dose ranging
GMP Grade
Clinical Manufacturing
Full regulatory compliance for human therapeutic applications.
- Phase I-III trials
- Commercial supply
- Regulatory filings
Stability Testing & Documentation
Comprehensive stability protocols and detailed Certificates of Analysis for complete traceability.
Stability Study Timeline
T0 - Release
Initial QC testing: HPLC purity, MS verification, endotoxin, concentration
3 Months
Accelerated stability at 37°C. Purity and integrity assessment.
12 Months
Long-term stability at recommended storage. Full analytical panel.
24+ Months
Extended stability data for GMP materials. Annual testing protocol.
Storage Conditions
-
-20°C to -80°C
Long-term storage (2+ years). Lyophilized or suspended in TE buffer.
-
4°C
Short-term storage (1-2 weeks). Suitable for working aliquots.
-
Room Temperature
Stabilized formats only. Modified RNA with enhanced stability.
-
RNase-free Water
Resuspension buffer. Avoid repeated freeze-thaw cycles.
Certificate of Analysis (COA)
Every batch includes comprehensive documentation for complete traceability
Batch Information
Lot #, Synthesis Date
Analytical Data
HPLC, MS, Purity %
Specifications
Sequence, Mods, Yield
QC Approval
Signed, Dated
Storage
Conditions, Stability
Compliance
ISO, GMP if applicable
Frequently Asked Questions
Common questions about our RNA QC standards and quality processes.
Each COA includes batch/lot number, synthesis date, sequence verification, molecular weight from MS analysis, HPLC purity chromatogram, endotoxin levels (if applicable), concentration determination, recommended storage conditions, and QA approval signature with date.
Research grade is suitable for assay development and routine lab work. Preclinical grade adds endotoxin testing and enhanced documentation for animal studies. GMP grade is required for human clinical trials and includes full regulatory documentation, validated processes, and DMF filing support.
When stored at -20°C to -80°C in RNase-free conditions, unmodified RNA standards are stable for at least 24 months. Modified RNAs (2'-OMe, 2'-F) show enhanced stability. Each COA specifies the expiration date based on real-time stability testing.
Yes, we offer both catalog and custom RNA QC standards. Custom sequences can be designed to match your specific assay requirements, including specific modifications, labels, or lengths. Contact our team for custom synthesis consultation.
For sensitive cell-based assays, we recommend endotoxin levels <0.1 EU/μg (Preclinical and GMP grades). Research grade materials may contain higher levels suitable for biochemical assays but not recommended for cell culture work.
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