Etoposide

Etoposide is a topoisomerase II inhibitor that induces DNA strand breaks by preventing the re-ligation of cleaved DNA. This mechanism leads to apoptosis, making etoposide a useful tool in studying DNA damage pathways in neurons. It is also used in models of neurotoxicity and to investigate the role of DNA repair in neurodegenerative conditions.

Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.

Safety Phrases:

• S22 - Do not breathe dust
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S53 - Avoid exposure - obtain special instruction before use

Risk Phrases:

• R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
• R45 - May cause cancer
• R62 - Possible risk of impaired fertility
• R68 - Possible risk of irreversible effects

Hazard Phrases:

H302-H350

Precautionary Phrases:

P201-P308 + P313

Etoposide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-244)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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