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Autophagy & Lysosomal Biology
Research-use ELISA kits, antibodies, and proteins for autophagy and lysosomal targets — LC3, p62/SQSTM1, Beclin-1, the ATG system, ULK1, and LAMP/cathepsin lysosomal markers.
457Products
5 of 457 products
| Image | Product | Target | Application(s) | Reactivity | Price | Status | ACTION |
|---|---|---|---|---|---|---|---|
|
Target: Beclin-1 |
Beclin-1 | Dot Blot, ELISA | Human |
From $211.15
Regular price
From $211.15
|
In Stock at Manufacturer | |
|
Target: Beclin-1 |
Beclin-1 | Western Blot, ELISA | Zebrafish |
From $211.15
Regular price
From $211.15
|
In Stock at Manufacturer | |
|
Target: Beclin-1 |
Beclin-1 | Immunohistochemistry, Western Blot | — |
From $296.00
Regular price
From $296.00
|
In Stock at Manufacturer | |
|
Target: Beclin-1 |
Beclin-1 | Immunohistochemistry, Western Blot | — |
From $296.00
Regular price
From $296.00
|
In Stock at Manufacturer | |
|
Target: Beclin-1 |
Beclin-1 | Immunohistochemistry, Western Blot | — |
From $296.00
Regular price
From $296.00
|
In Stock at Manufacturer |
About Autophagy & Lysosomal Biology
Antibodies, assay kits, and proteins for studying autophagy and lysosomal biology. The category covers the core autophagy machinery (LC3/ATG8, ATG5–ATG12, Beclin-1, ULK1), the selective-autophagy adaptor p62/SQSTM1, upstream regulators (mTOR, AMPK), and lysosomal markers and hydrolases (LAMP1/2, cathepsins). Use it to source validated reagents for autophagy-flux, lysosomal-function, and protein-degradation research across human and preclinical species.
About Autophagy & Lysosomal Biology
Autophagy and lysosomal biology cover the cell’s catabolic machinery — the pathways that capture damaged proteins, aggregates, and whole organelles and route them to the lysosome for degradation and nutrient recycling, especially under nutrient or energy stress. This collection gathers ELISA kits, antibodies, and proteins for the core autophagy and lysosomal targets: LC3, SQSTM1/p62, Beclin-1, the ATG conjugation system (ATG5/ATG7/ATG12), ULK1, and lysosomal membrane and enzyme markers (LAMP1/2, cathepsins, GAA).
Reading the cell’s disposal systems: Autophagy vs Ubiquitin–Proteasome vs Apoptosis
Three degradation systems keep a cell healthy, and they answer different questions. Autophagy/lysosomal degradation is the system in this collection; the table shows when to reach for it versus its two siblings.
| Dimension | Autophagy & Lysosomal | Protein Quality Control (Ubiquitin–Proteasome) | Apoptosis & Cell Death |
|---|---|---|---|
| What it removes | Bulk cytoplasm, aggregates, whole organelles (e.g. mitophagy) | Individual poly-ubiquitin-tagged proteins | The entire cell (programmed death) |
| Degradation site | Lysosome | 26S proteasome | Executioner caspases (no single organelle) |
| Core machinery | ATG proteins, LC3 lipidation, autophagosome → lysosome | E1/E2/E3 ligases, proteasome, chaperones | Bcl-2 family, caspases, cytochrome c |
| Key markers | LC3-II, SQSTM1/p62, Beclin-1, LAMP1/2 | Ubiquitin, proteasome subunits, HSPs | Cleaved caspase-3, Annexin V, cytochrome c |
| Typical trigger | Nutrient/energy stress, damaged organelles | Misfolded or excess proteins | Irreparable damage, death signals |
| Outcome | Survival & recycling | Proteostasis | Cell elimination |
| Watch-outs | p62 falls with flux but rises when flux is blocked — interpret with LC3 turnover (± lysosomal inhibitor), not a single snapshot | Ubiquitin signal is not proof of proteasomal fate | Early vs late markers differ; use a time course |
How to read this: use Autophagy & Lysosomal when the target is bulk or organelle recycling routed to the lysosome. When your target is a single ubiquitin-tagged protein, use Protein Quality Control; when the readout is whether the cell lives or dies, use Apoptosis & Cell Death. The systems cross-talk — blocking autophagy can tip stressed cells toward apoptosis — so many studies assay more than one.
Recommended autophagy & lysosomal kits
Human Beclin-1 (BECN1) ELISA Kit
View product →Human SQSTM1 / p62 ELISA Kit
View product →Human ATG7 ELISA Kit
View product →Human LAMP1 ELISA Kit
View product →Related reading
Monitoring autophagic flux: LC3-II and p62 together
Selective autophagy: mitophagy and aggrephagy markers
Lysosomal function readouts (LAMP, cathepsins)