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Neural Circuit Tracing Solutions

Comprehensive viral vector-based neural circuit mapping services. From rabies virus monosynaptic tracing to VSV anterograde mapping, we provide end-to-end solutions for deciphering brain connectivity.

5
Viral Platforms
50+
Strain Variants

Viral Vector Platforms

Select from our comprehensive suite of neurotropic viral vectors, each optimized for specific circuit tracing applications

Rabies Virus (RV)
Retrograde monosynaptic tracing with ΔG-RV system. Gold standard for input mapping.
Retrograde Monosynaptic →
Pseudorabies (PRV)
Retrograde polysynaptic tracing. Bartha strain for multi-order circuit analysis.
Retrograde Polysynaptic →
HSV (H129)
Anterograde polysynaptic tracing. H129 strain for output network mapping.
Anterograde Polysynaptic →
VSV Vectors
Bidirectional tracing with glycoprotein pseudotyping. Rapid gene expression.
Bidirectional Configurable →

Featured Case Studies

🧠
Parkinson's Research
Cortico-Striatal Input Mapping
Mapped monosynaptic inputs to striatal medium spiny neurons in a 6-OHDA Parkinson's disease mouse model using ΔG-Rabies. Identified altered cortical inputs to D1 vs D2 receptor-expressing neurons.
Virus Used RV-SAD-B19-EGFP
Target Region Dorsal Striatum
Sample Size 24 mice (3 groups)
Turnaround 5 weeks
❤️
Cardiovascular
Baroreceptor Circuit Hierarchy
Used PRV-Bartha to map complete neural hierarchy from carotid body baroreceptors through nodose ganglia to NTS and RVLM in rat models of hypertension.
Virus Used PRV-152 & PRV-614
Injection Site Carotid Sinus
Survival Time 96 hours
Analysis Whole-brain clearing
👁️
Visual System
Corticothalamic Feedback
Mapped Layer 6 cortical feedback projections to dorsal lateral geniculate nucleus (dLGN) using HSV-1 H129 anterograde tracing in ferret visual development models.
Virus Used H129-ΔTK-mCherry
Source Visual Cortex L6
Timepoint P21 (Development)
Imaging Confocal + Light-sheet

Detailed Applications

1

Input Connectivity Mapping (Retrograde)

Identify monosynaptic inputs to genetically defined cell populations using ΔG-Rabies. Essential for understanding how specific neuronal types integrate into broader circuits.

Rabies Virus Monosynaptic Cell-type Specific
2

Peripheral-CNS Circuit Tracing

Map complete autonomic pathways from organs to central control centers using PRV polysynaptic tracing. Ideal for cardiovascular, gastrointestinal, and metabolic research.

PRV Bartha Polysynaptic Autonomic Nervous System
3

Output Network Analysis (Anterograde)

Determine downstream projection targets of specific brain regions using HSV-1 H129. Critical for understanding information flow and network hierarchies.

HSV H129 Anterograde Multi-order
4

Time-Critical Tracing

Rapid circuit mapping in acute preparations or disease models with limited survival windows using VSV vectors with 1-hour expression onset.

VSV Rapid Expression Acute Slices

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