Difluoromethylornithine

Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, a key enzyme in polyamine biosynthesis. While primarily studied for its anti-cancer, anti-parasitic, and anti-angiogenic properties, DFMO has emerging relevance in neurodegenerative disease research. Polyamines are implicated in neuronal growth, differentiation, and synaptic plasticity, but their dysregulation contributes to neurotoxicity and oxidative stress. By modulating polyamine levels, DFMO may help mitigate excitotoxicity and inflammation in neurodegenerative conditions such as Alzheimer's disease and Huntington's disease. Its potential to reduce neuronal apoptosis and modulate neuroinflammation positions DFMO as a candidate for therapeutic intervention in neurodegeneration.

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases:

• S22 - Do not breathe dust
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Difluoromethylornithine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-200)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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