| Field | Specification |
|---|---|
| Activity | |
| Alternative Names | 2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide, 5,5-Dimethyl-1-Pyrroline-N-Oxide, 3,4-dihydro-2,3-dimethyl-2H-pyrrole 1-oxide |
| Cas No. | |
| Form | Liquid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in ethanol and to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
DMPO (5,5-dimethyl-1-pyrroline N-oxide) is a spin trap used to detect reactive oxygen species and free radicals in biological systems. Its low toxicity and favorable pharmacokinetics make it suitable for in vivo studies. DMPO adducts can be formed with protein and DNA radicals, aiding in the investigation of oxidative stress—a key contributor to neurodegenerative diseases. Caution is advised when interpreting results in the presence of nitric oxide due to potential interference.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with shin and eyes
DMPO (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-324)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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2. Ramirez D.C., Gomez-Mejiba S.E., and Mason R.P. (2007) Nat Protoc. 2(3): 512-522.
3. Khan N., et al. (2003) Free Radic. Biol. Med 34:1473–1481.
4. Haseloff R.F., et al. (1997) FEBS Lett 418:73–75.
5. Schaefer C.F., Janzen E.G., West M.S., Poyer J.L., and Kosanke S.D. (1996) Free Radic. Biol. Med 21:427–436.
6. Anzai K., et al. (2003) Arch. Biochem. Biophys 415:251–256.
7. Chatterjee S., Ehrenshaft, M., Bhattacharjee ,S., Derterding, L.J., Bonini, M.G., Corbett, J., Kadiiska, M.B., Tomer K.B. and Mason, R.P. 2009 Free Radic. Med. and Biol. 46:454-461.
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