Garcinol

Garcinol is a natural, cell-permeable inhibitor of histone acetyltransferases p300 and pCAF (IC₅₀ = 7 µM and 5 µM, respectively). It induces apoptosis, promotes hematopoietic stem cell expansion, and exhibits anti-inflammatory properties.

In neuroscience, Garcinol has been shown to promote neurogenesis in cortical progenitor cells and suppress neuroinflammation in Alzheimer’s models by modulating NF-κB signaling. Its ability to regulate histone acetylation and transcriptional activity positions it as a promising compound for exploring epigenetic therapies in neurodegenerative diseases.

Classification: Caution- Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S24/25- Avoid contact with skin and eyes

Garcinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-355)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).