MG-132

MG-132 is a specific inhibitor of the 20S proteasome, blocking NF-κB activation by preventing IκB proteolysis. It stimulates autophagy and induces the heat shock response, making it a valuable tool in studying protein degradation and stress pathways. In neuroscience, MG-132 is used to investigate proteostasis, neuroinflammation, and the role of ubiquitin-proteasome system dysfunction in neurodegenerative diseases.

Classification: Caution: Substance not yet fully tested.

Safety Phrases:

• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S24/25- Avoid contact with skin and eyes

MG-132 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-326)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).