| Field | Specification |
|---|---|
| Alternative names | N-[(Benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxo-2-pentanyl]-L-leucinamide, Z-Leu-Leu-Leu-al, Z-LLL-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C26H41N3O5 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in 45 mg/ml DMSO, DMF and ethanol |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
MG-132 is a specific inhibitor of the 20S proteasome, blocking NF-κB activation by preventing IκB proteolysis. It stimulates autophagy and induces the heat shock response, making it a valuable tool in studying protein degradation and stress pathways. In neuroscience, MG-132 is used to investigate proteostasis, neuroinflammation, and the role of ubiquitin-proteasome system dysfunction in neurodegenerative diseases.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
MG-132 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-326)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Wu W.K., et al. (2010) Autophagy 6:228.
3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.
