| Field | Specification |
|---|---|
| Alternative names | 2-Phenylethynesulfonamide, PFTµ |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C8H7NO2S |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in ethanol (110 mM) and in DMSO (110 mM) |
| SMILES | |
| InChIKey | |
| Form | White to off-white solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Pifithrin mu selectively interacts with HSP70, disrupting its association with co-chaperones and substrate proteins. It inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. This dual action promotes apoptosis and modulates stress response pathways. In neurodegenerative research, Pifithrin mu is used to study protein folding, mitochondrial integrity, and apoptotic regulation.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Phrases:
H302-H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Pifithrin mu (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-325)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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