| Field | Specification |
|---|---|
| Alternative names | (±)-N-Cyano-N′-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate, PINACIDIL MONOHYDRATE; Pindac; Pinacidil hydrate; 85371-64-8; Pinacidil anhydrous; CHEBI:34923, Pindac |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C13H19N5 · H2O |
| Purity | |
| Bioactivity | Activator |
| Activity | |
| Solubility | May be dissolved in DMSO (25 mg/ml, warm); or ethanol (25 mg/ml, warm) |
| SMILES | |
| InChIKey | |
| Form | White powder |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Pinacidil Monohydrate is a potassium channel opener that activates ATP-sensitive K⁺ (K_ATP) channels, leading to membrane hyperpolarization and reduced cellular excitability. In neuroscience, Pinacidil is used to study neurovascular coupling, mitochondrial function, and neuroprotection. Its ability to modulate ion channel activity and reduce calcium influx makes it relevant in models of ischemia, epilepsy, and neurodegeneration. Pinacidil is also investigated for its role in preserving mitochondrial integrity and reducing oxidative stress in neurons.
WHMIS Classification: D2B Toxic Material Causing Other Toxic Effects: Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
GHS Classification: Acute toxicity, Oral (Category 4)
Skin irritation (Category 2)
Eye irritation (Category 2A)
Specific target organ toxicity - single exposure (Category 3), Respiratory system
GHS Label elements, including precautionary statements
Signal word:
Warning
Hazard statement(s):
- H302 Harmful if swallowed.
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
Precautionary statement(s):
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Pinacidil Monohydrate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-563)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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