Tranilast

Tranilast is an antiallergic and antifibrotic compound increasingly explored in neurodegenerative disease research for its ability to modulate inflammatory and fibrotic pathways. It inhibits collagen synthesis in a dose-dependent manner and suppresses transforming growth factor-beta (TGF-β), a cytokine implicated in neuroinflammation and glial scarring. These properties suggest potential therapeutic relevance in conditions such as multiple sclerosis and Alzheimer’s disease, where fibrosis and chronic inflammation contribute to disease progression. While traditionally used in allergy and oncology research, Tranilast’s emerging role in modulating neuroimmune responses positions it as a candidate for repurposing in neuroprotective strategies.

Classification: Caution: Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Phrases:

• H302 – Harmful if swallowed.
• H312 – Harmful in contact with skin.
• H332 – Harmful if inhaled.

Precautionary Phrases:

• P261 – Avoid breathing dust/fume/gas/mist/vapours/spray
• P280 – Wear protective gloves/protective clothing/eye protection/face protection.
• P301+ P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
• P304+P340 – IF INHALED: remove victim to fresh air and keep at rest in a position comfortable for breathing.
• P501 – Dispose of contents/container in accordance with local/regional/national/ international regulations.

Tranilast (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-369)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).