U-Blot® CLUS Rabbit Polyclonal Antibody

SKU:BHA21810976
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    Overview
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    Anti-CLUS antibody (Rabbit host, polyclonal, Unconjugated). Validated for Western Blot, ELISA with reactivity to Human, Mouse, Rat.
    Clonality Polyclonal
    Host Rabbit
    Reactivity Human, Mouse, Rat
    Conjugate Unconjugated
    Isotype IgG
    Applications Western Blot, ELISA
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    Options selector
    Catalog no. Size
    WP16034-50 50 uL
    WP16034-100 100 uL
    Available Options

    Select the variant that best fits your experiment. Availability and lead time may vary by option.

    • Options: Size: 50 uL
    • Lead time: options listed in "Availability Content"; other statuses may take longer.
    • Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
    • Shipping: cold-chain shipment (typically with ice packs).
    • Upon receipt: store at recommended temperature as soon as possible.
    • Sales terms and conditions: Please review prior to ordering.
    Field Specification
    Alternative Names Clusterin;Aging-associated gene 4 protein;Apolipoprotein J;Apo-J;Complement cytolysis inhibitor;CLI;Complement-associated protein SP-40,40;Ku70-binding protein 1;NA1/NA2;Testosterone-repressed prostate message 2;TRPM-2;[Cleaved into: Clusterin beta chain;ApoJalpha;Complement cytolysis inhibitor a chain;Clusterin alpha chain;ApoJbeta;Complement cytolysis inhibitor b chain;]
    Antigen
    • Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40
    • 40) (Ku70-binding protein 1) (NA1/NA2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain)]
    Cellular Localization [Isoform 1]: Secreted . Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. .; [Isoform 4]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .; [Isoform 6]: Cytoplasm . Keeps cytoplasmic localization in stressed and unstressed cell. .; Nucleus . Cytoplasm . Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cytosol . Microsome . Endoplasmic reticulum . Mitochondrion . Mitochondrion membrane . Cytoplasm, perinuclear region . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress (PubMed:17451556). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (PubMed:20068069). Detected at the mitochondrion membrane upon induction of apoptosis (PubMed:17689225). Under ER stress, a immaturely glycosylated pre-secreted form retrotranslocates from the endoplasmic reticulum (ER)-Golgi network to the cytoplasm to localize in the mitochondria through HSPA5 interaction (PubMed:22689054). ER stress reduces secretion (PubMed:22689054). Under the stress, minor amounts of non-secreted forms accumulate in cytoplasm (PubMed:24073260, PubMed:22689054, PubMed:17451556). Non-secreted forms emerge mainly from failed translocation, alternative splicing or non-canonical initiation start codon (PubMed:24073260, PubMed:12551933). .
    Clonality
    • Polyclonal
    Concentration 1 mg/ml
    Conjugate
    • Unconjugated
    Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Gene ID 1191 (Human) | 12759 (Mouse) | 24854 (Rat)
    Host Rabbit
    Immunogen Synthesized peptide derived from human CLUS Polyclonal
    Isotype
    • IgG
    Molecular Weight Observed: 52 kDa
    Product Type
    • Polyclonal Antibody
    • Primary Antibodies
    Reactivity
    • Human
    • Mouse
    • Rat
    Storage -15°C to -25°C/1 year(Do not lower than -25°C)
    Target CLUS
    Antibody

    Product Overview

    U-Blot® CLUS Rabbit Polyclonal Antibody is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against CLUS. It has been validated for Western Blot, ELISA and reacts with Human, Mouse, Rat.

    Validated Applications

    Target CLUS
    Host Rabbit
    Clonality Polyclonal
    Isotype IgG
    Conjugate Unconjugated
    Reactivity Human, Mouse, Rat
    Applications Western Blot, ELISA
    Purification Affinity Purified
    Specificity This antibody detects endogenous levels of CLUS.
    Molecular Weight Observed: 52 kDa
    UniProt / Swiss-Prot P10909 (Human) | Q06890 (Mouse) | P05371 (Rat)

    Recommended dilutions: WB 1:500-2000;ELISA 1:10000-20000

    Immunogen / Antigen

    Synthesized peptide derived from human CLUS Polyclonal

    Reactivity Notes

    Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.

    Scientific Background

    The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

    Safety & Handling

    For Research Use Only (RUO). Not for diagnostic or therapeutic use. Store as indicated: -15°C to -25°C/1 year(Do not lower than -25°C)
    What applications is this antibody validated for?

    This antibody is validated for Western Blot, ELISA. Recommended dilutions: WB 1:500-2000;ELISA 1:10000-20000

    What species does it react with?

    Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.

    Is this antibody conjugated?

    Conjugate: Unconjugated.

    How should it be stored?

    Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)

    Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.

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