| Field | Specification |
|---|---|
| Alternative Names | PTGS1;COX1;Prostaglandin G/H synthase 1;Cyclooxygenase-1;COX-1;Prostaglandin H2 synthase 1;PGH synthase 1;PGHS-1;PHS 1;Prostaglandin-endoperoxide synthase 1 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthetic Peptide of COX1 AA range: 483-533 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® COX1 Rabbit Polyclonal Antibody (WP5884) is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against COX1. It has been validated for Western Blot and reacts with Human.
Validated Applications
| Target | COX1 |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | The antibody detects endogenous COX1 proteins. |
| Molecular Weight | Observed: 70 kDa |
| UniProt / Swiss-Prot | P23219 (Human) | P22437 (Mouse) | Q63921 (Rat) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Synthetic Peptide of COX1 AA range: 483-533
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:1000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
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