| Field | Specification |
|---|---|
| Alternative Names | NR3C1;GRL;Glucocorticoid receptor;GR;Nuclear receptor subfamily 3 group C member 1 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Recombinant Protein of Glucocorticoid receptor |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® Glucocorticoid Receptor Rabbit Polyclonal Antibody is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against Glucocorticoid Receptor. It has been validated for Western Blot and reacts with Human, Mouse, Rat.
Validated Applications
| Target | Glucocorticoid Receptor |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | The antibody detects endogenous GR proteins. |
| Molecular Weight | Observed: 80-97 kDa |
| UniProt / Swiss-Prot | P04150 (Human) | P06537 (Mouse) | P06536 (Rat) |
Recommended dilutions: WB 1:1000-3000
Immunogen / Antigen
Recombinant Protein of Glucocorticoid receptor
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking pat
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:1000-3000
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
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