Complimentary Sample  ·  Kerry (formerly c-LEcta)  ·  Authorized US Distributor

Free 25 kU Sample
Denarase® & Denarase® High Salt

Nuclease selection is a process decision, not a catalogue decision. Benchmark nucleic acid clearance under your own buffer conditions before committing to a supply agreement.

0–500 mM salt tolerance  ·  Purity ≥ 98–99%  ·  Animal origin-free  ·  EU GMP and ISO 9001 grades

Held in US stock — R&D grade ships in 2–3 business days

Which variant fits your process?

Both variants hydrolyse single- and double-stranded, linear, circular and supercoiled DNA and RNA to fragments of roughly 3–5 base pairs. They differ in the salt window over which they stay active. If you are unsure, tell us your lysis conditions on the form below and we will recommend one.

Denarase® — Standard
Peak performance at 0–150 mM salt, pH 7.4–9. Purity ≥ 99%. The more economical choice at physiological conditions — the default for standard lysis workflows.
Denarase® High Salt
Engineered variant. Retains activity across 0–500 mM salt, pH 7.4–9. Purity ≥ 98%. Enables salt-supplemented lysis conditions that can improve viral vector recovery.

What the sample lets you establish

  • Working enzyme concentration for your lysate — evaluations typically start in the 10–100 U/mL range
  • Clearance performance at your actual salt and pH, and which variant suits your process window
  • Viscosity reduction and its downstream effect on filtration and chromatography
  • A residual endonuclease baseline, which the Denarase® ELISA Kit can then quantify during validation

From evaluation to GMP supply

R&D and GMP grades are released against identical specifications, so process data generated on the sample carries forward without repeating enzyme characterisation. A Change Guidance Document is supplied for the grade transition, and regulatory support documentation is available on request. BioHippo is Kerry's authorized United States distributor for the Denarase® portfolio.

Sample available for: Denarase®  ·  Denarase® High Salt

Specifications sourced from Kerry product documentation. Denarase® is a registered trademark of c-LEcta GmbH, a Kerry company. Benzonase® is a registered trademark of Merck KGaA. For research and manufacturing use; not for therapeutic or diagnostic use in humans.

Request your 25 kU sample

Sample requests are reviewed by our technical team so we send the right variant for your process. Tell us your lysis conditions and we will confirm within one business day.

One sample per organisation, R&D grade, subject to availability.

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