| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate |
| Cas No. | |
| Form | White to off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in methanol (50 mg/ml) or ethanol; very slightly soluble in water or acetone. |
| Source | Synthetic |
| Storage |
Tamoxifen Citrate is a selective estrogen receptor modulator (SERM) primarily used in breast cancer therapy. In neuroscience, Tamoxifen has gained attention for its ability to modulate estrogen signaling in the brain, which influences neuroprotection, synaptic plasticity, and cognitive function. Estrogen receptors are expressed in various brain regions, and their activation has been linked to reduced neuroinflammation and oxidative stress. Tamoxifen also exhibits estrogen receptor-independent effects, including inhibition of protein kinase C, which may influence neuronal signaling pathways. Furthermore, Tamoxifen is widely used in inducible Cre-loxP systems for conditional gene knockout studies in neuroscience, enabling precise temporal and spatial control of gene expression in the brain. Its role in autophagy and cellular stress responses adds to its relevance in neurodegenerative disease models.
Classification: D2A- Very Toxic Material Causing Other Toxic Effects, Teratogen, Carcinogen, Reproductive hazard
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H302- Harmful if swallowed.
- H350- May cause cancer.
- H360- May damage fertility or the unborn child.
Precautionary statements:
- P201- Obtain special instructions before use.
- P308 + P313- IF exposed or concerned: Get medical advice/ attention.
Tamoxifen Citrate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-389)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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2. Ma, J. et al. (2014). BMC Cancer, 14: 172.
3. Patel, S. et al. (2012). Int J Radiat Oncol Biol Phys, 82(2): 739-42.
4. Wang, D. et al. (2004). Mol Endocrinol. 402-11.
