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Compound Overview
15-deoxy-Δ12,14-Prostaglandin D2 (CAS 85235-11-6) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 85235-11-6 |
|---|---|
| Molecular Formula | C20H30O4 |
| Molecular Weight | 334.46 g/mol |
| SMILES | CCCCCC=CC=C1/(CH)(CC=C/CCCC(O)=O)(CH)(O)CC1=O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
15-deoxy-delta12,14-Prostaglandin D2 (15-deoxy-delta12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor gamma (PPARgamma), initiating PPARgamma-mediated transcription at 5 uM concentration. Furthermore, it exhibits cytotoxicity towards L1210 murine leukemia cells with an IC50 of 0.3 ug/ml and displays weaker inhibition of ADP-induced platelet aggregation than PGD2, with an IC50 of 320 ng/ml.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
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