17-AAG

17-AAG (17-allylamino-17-demethoxygeldanamycin) is a potent inhibitor of heat shock protein 90 (HSP90), a molecular chaperone essential for the stability and function of numerous client proteins involved in cell signaling, survival, and protein homeostasis. Originally developed as an anticancer agent due to its selective affinity for tumor-derived HSP90, 17-AAG has gained attention in neuroscience for its ability to modulate protein degradation pathways. Notably, 17-AAG induces autophagy, a cellular clearance mechanism critical for the removal of misfolded proteins such as alpha-synuclein—an aggregation-prone protein implicated in Parkinson’s disease and other synucleinopathies. By promoting autophagic flux, 17-AAG may help restore proteostasis in neural cells and reduce neurotoxicity associated with protein aggregation. Its dual role in inhibiting Akt signaling and enhancing protein clearance positions 17-AAG as a promising candidate for therapeutic exploration in neurodegenerative disorders characterized by proteotoxic stress.

Classification: Caution: Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

17-AAG (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-100)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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