| Field | Specification |
|---|---|
| Alternative names | Alvespimycin, 17DMAG, 17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin, 17-desmethoxy-17-n,n-dimethylaminoethylamino-geldanamycin, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin, 17-DMAG, 17-Dimethylaminoethylamino, 17-Demethoxygeldanamycin, [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-21-[2-(dimethylamino)ethylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C32H48N4O8 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in DMSO (30 mg/ml) and ethanol (10 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | Purple Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin) is a water-soluble, bioavailable analog of geldanamycin and 17-AAG, designed to overcome the solubility and toxicity limitations of its predecessors. As a high-affinity HSP90 inhibitor, 17-DMAG disrupts the stability of client proteins involved in neurodegenerative disease pathways. Preclinical studies highlight its ability to induce autophagy and promote the clearance of alpha-synuclein aggregates, a hallmark of Parkinson’s disease and related disorders. Its favorable pharmacokinetic profile, including efficient tissue distribution and reduced metabolic degradation, makes 17-DMAG a compelling candidate for CNS-targeted therapies. By enhancing proteostasis and mitigating protein aggregation, 17-DMAG represents a promising tool for modulating neurodegenerative processes at the molecular chaperone level.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
17-DMAG (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-114)
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2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381.
3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813. 4. RA Frake et al. (2015) J Clin Invest. 125(1): 65-74.
