| Field | Specification |
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| Activity | |
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| Product Type | |
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Compound Overview
2,3-dinor-8-iso Prostaglandin F2α (CAS 221664-05-7) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 221664-05-7 |
|---|---|
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
8-isoProstaglandin F2alpha (8-isoPGF2alpha; 8-isoprostane) is a byproduct of non-specific lipid peroxidation, resembling prostaglandin in structure. In humans and rats, its metabolite, 12,3-dinor-8-isoPGF2alpha, is formed following exogenous administration of 8-isoPGF2alpha, which is converted to 2,3-dinor-8-isoPGF1alpha and 2,3-dinor-8-isoPGF2alpha. Additionally, rat hepatocytes can further break down 8-isoPGF2alpha into a beta-oxidation product, 2,3,4,5-tetranor-8-isoPGF2alpha. The metabolite, 2,3-dinor-8-isoPGF2alpha, is normally found in human urine at concentrations of 200-300 pg/ml. Its levels rise in conditions associated with oxidative stress, such as smoking, demonstrating a correlation with the concentration of its precursor, 8-isoPGF2alpha.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Solubility data for each compound is provided on the TargetMol product page and DataSheet, listed as maximum solubility in DMSO and/or aqueous media (mg/mL and mM). For compounds not yet characterized, prepare a test dissolution at the intended stock concentration and visually confirm clarity before use. When preparing aqueous working solutions, always dilute from a DMSO stock and monitor for precipitation at your final assay concentration.
If you are using DMSO for preparation,sterilization is not recommended, as DMSO itself possesses strong sterilizing properties. The prepared solution is sterile. For further assurance, it can be left overnight at 4°C. The safest method is to filter through a specialized organic filter membrane. If water is used for preparation,sterilization can be achieved by filtering through a 0.22 μm filter membrane.
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