| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Celecoxib-13 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
2,5-dimethyl Celecoxib (CAS 457639-26-8) is a research-grade small molecule supplied by TargetMol.
Alternative names: Celecoxib-13
Physical Properties
| CAS Number | 457639-26-8 |
|---|---|
| Molecular Formula | C18H16F3N3O2S |
| Molecular Weight | 395.40 g/mol |
| SMILES | CC1=CC(C2=CC(=NN2C2=CC=C(C=C2)S(N)(=O)=O)C(F)(F)F)=C(C)C=C1 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), a key enzyme in the PGE2 synthesis pathway of inflammatory mediators.
Target(s): Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor
Signaling pathway(s): Immunology/Inflammation, Apoptosis, GPCR/G Protein, Cytoskeletal Signaling, Stem Cells
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
After the stock solution is prepared, it is typically stored at -80°C and can be kept for over 1 year. It is recommended to aliquot to avoid repeated freeze-thaw cycles. For frequent use, it can be stored at 4°C for over a week.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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