3-AQC

Product details

• Chemical name: 3-(4-allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate.
• CAS number: 149685-89-2
• Molecular formula: C20H21N5O4.
• Purity: >98%
• Concentration: 1-100 µM.
• Form: Lyophilized powder.
• Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: 5-HT3A channel
• Source: Synthetic
• Activity: 3-AQC is a potent and selective 5-HT3A receptor antagonist1.

Scientific background

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.3-AQC is a potent and selective antagonist of the 5-HT3A channel. 3-AQC is a derivative of Piperazinyquinoxaline synthetically designed to be 100 times more potent in blocking Serotonin receptors than Tropisetron.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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