| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-MA, 3-Methyl-3H-purin-6-amine |
| Cas No. | |
| Form | White solid. |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm). |
| Source | Synthetic |
| Storage |
3-Methyladenine (3-MA) is a widely used inhibitor of phosphatidylinositol 3-kinase (PI3K), effectively blocking autophagy by preventing autophagosome formation. In neuroscience and neurodegenerative disease research, 3-MA serves as a critical tool for dissecting the role of autophagy in neuronal survival and death. Dysregulated autophagy is a hallmark of several neurodegenerative disorders, including Alzheimer’s, Parkinson’s, and Huntington’s diseases. By modulating autophagic flux, 3-MA enables researchers to explore therapeutic strategies aimed at restoring cellular homeostasis and preventing neurodegeneration.
Classification: Not WHMIS controlled.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
3-Methyladenine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-408)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64.
3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61.
